DESCRIBE <http://purl.uniprot.org/citations/22342686>

Subject	Predicate	Object
http://purl.uniprot.org/citations/22342686	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22342686	http://www.w3.org/2000/01/rdf-schema#comment	" Objectives Root resorption is a ubiquitous although undesirable sequela to orthodontic treatment. Current methods to investigate the pathophysiology have certain limitations. In pursuit to understand and develop treatment modalities for orthodontically induced root resorption, the ability to manipulate cells within their natural extracellular matrix in a three dimensional organotypic model is invaluable. The study aimed to develop a laboratory-based organotypic model to investigate the effect of orthodontic forces on the periodontium. Methods Mandibular slices of male Wistar rats were maintained in Trowel-typed cultures at 37°C in 5% carbon dioxide in air for 7 days with test specimens subjected to compressive forces at 50 g and 100g by stainless steel springs. Tissue architecture and cell viability were maintained under culture conditions. Results Osteoclast numbers increased significantly in both test groups whilst odontoclasts increased in the 50 g group. Immunohistochemistry demonstrated increased dentine sialoprotein expression in both test groups, suggesting changes in mineralization-related activity due to mechanical strain. Conclusion The study showed initial cellular and molecular changes of key markers that relate to root resorption in response to mechanical loading. Clinical significance Severe root resorption may occur when forces applied are heavy or transmitted over an extended period and could lead to mobility and tooth loss. This ex vivo model can be used to investigate cellular and molecular processes during orthodontic tooth movement which may advance the clinical management of root resorption."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.org/dc/terms/identifier	"doi:10.1016/j.jdent.2012.02.002"xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/author	"Sloan A.J."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/author	"Waddington R.J."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/author	"Stephenson P.A."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/author	"Wan Hassan W.N."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/date	"2012"xsd:gYear
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/name	"J Dent"xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/pages	"406-415"xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/title	"An ex vivo culture model for orthodontically induced root resorption."xsd:string
http://purl.uniprot.org/citations/22342686	http://purl.uniprot.org/core/volume	"40"xsd:string
http://purl.uniprot.org/citations/22342686	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/22342686
http://purl.uniprot.org/citations/22342686	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/22342686
http://purl.uniprot.org/uniprot/Q62598#attribution-C850E6FDF9213F0243C3065ED08600BD	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/#_E9PTW3-mappedCitation-22342686	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/#_F1MAQ2-mappedCitation-22342686	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/#_Q62598-mappedCitation-22342686	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/#_Q8VBY1-mappedCitation-22342686	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/F1MAQ2	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/Q62598	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/Q8VBY1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22342686
http://purl.uniprot.org/uniprot/E9PTW3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22342686