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http://purl.uniprot.org/citations/22348533http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22348533http://www.w3.org/2000/01/rdf-schema#comment"

Background

The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly. To investigate possible dynamic mechanisms of DNA methylation inheritance during the cell cycle, we used a Proximity Ligation In Situ Assay (P-LISA) to analyze the kinetic of formation and DNA recruitment of Dnmt1-including complexes.

Results

P-LISA, sequential chromatin immunoprecipitation and quantitative methylation specific PCR revealed that the Dnmt1/PCNA/UHRF1-including complexes are mainly formed and recruited on DNA during the S-phase of cell cycle, while the formation and the DNA recruitment of several Dnmt1/transcription factors-including complexes are not S-phase dependent but are G0/G1 and/or G2/M phases dependent.

Conclusion

Our data confirm that DNA methylation inheritance occurs in S-phase, and demonstrate that DNA methylation inheritance can also occur in G0/G1 and G2/M phases of the cell cycle."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.org/dc/terms/identifier"doi:10.1186/1747-1028-7-5"xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/author"Vallette F.M."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/author"Cartron P.F."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/author"Hervouet E."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/author"Gueguen M."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/author"Nadaradjane A."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/name"Cell Div"xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/pages"5"xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/title"Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle."xsd:string
http://purl.uniprot.org/citations/22348533http://purl.uniprot.org/core/volume"7"xsd:string
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