| http://purl.uniprot.org/citations/22354040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22354040 | http://www.w3.org/2000/01/rdf-schema#comment | "In Saccharomyces cerevisiae, the telomerase complex binds to chromosome ends and is activated in late S-phase through a process coupled to the progression of the replication fork. Here, we show that the single-stranded DNA-binding protein RPA (replication protein A) binds to the two daughter telomeres during telomere replication but only its binding to the leading-strand telomere depends on the Mre11/Rad50/Xrs2 (MRX) complex. We further demonstrate that RPA specifically co-precipitates with yKu, Cdc13 and telomerase. The interaction of RPA with telomerase appears to be mediated by both yKu and the telomerase subunit Est1. Moreover, a mutation in Rfa1 that affects both the interaction with yKu and telomerase reduces the dramatic increase in telomere length of a rif1Δ, rif2Δ double mutant. Finally, we show that the RPA/telomerase association and function are conserved in Schizosaccharomyces pombe. Our results indicate that in both yeasts, RPA directly facilitates telomerase activity at chromosome ends."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2012.40"xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Gilson E."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Simon M.N."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Brill S.J."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Bos J."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Geli V."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Luciano P."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Corda Y."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Coulon S."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/author | "Faure V."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/pages | "2034-2046"xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/title | "RPA facilitates telomerase activity at chromosome ends in budding and fission yeasts."xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22354040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22354040 |
| http://purl.uniprot.org/citations/22354040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22354040 |
| http://purl.uniprot.org/uniprot/P22336#attribution-B56B3FBCDB2F4B7FC1074A9C0F41EA9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22354040 |
| http://purl.uniprot.org/uniprot/P26754#attribution-B56B3FBCDB2F4B7FC1074A9C0F41EA9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22354040 |
| http://purl.uniprot.org/uniprot/P26755#attribution-B56B3FBCDB2F4B7FC1074A9C0F41EA9F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22354040 |
| http://purl.uniprot.org/uniprot/Q92372#attribution-2FB3BB5E1BF34C1817BC2B0550FB2BBF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22354040 |
| http://purl.uniprot.org/uniprot/Q92372#attribution-4F75E9D27BC4E0C95721F849CE01CEBC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22354040 |
| http://purl.uniprot.org/uniprot/#_A0A8H4FAY7-mappedCitation-22354040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22354040 |