| http://purl.uniprot.org/citations/22355400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22355400 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n = 161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV-cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV-cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p = 0.028), EBV- cHL vs controls (p = 0.045) and EBV+ vs EBV-cHL cases (p = 2×10(-5)). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV-cHL in the northern Chinese population."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0031865"xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Gao Z."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Huang X."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Visser L."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Nolte I."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Diepstra A."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "van den Berg A."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Poppema S."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Hepkema B."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Jongsma T."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Veenstra R."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/author | "Kushekhar K."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/pages | "e31865"xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/title | "HLA-A*02:07 is a protective allele for EBV negative and a susceptibility allele for EBV positive classical Hodgkin lymphoma in China."xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22355400 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22355400 |
| http://purl.uniprot.org/citations/22355400 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22355400 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-22355400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355400 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-22355400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355400 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-22355400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355400 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-22355400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355400 |