| http://purl.uniprot.org/citations/22355679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22355679 | http://www.w3.org/2000/01/rdf-schema#comment | "UVB-induced cutaneous photodamage/photoaging is characterized by qualitative and quantitative deterioration in dermal extracellular matrix (ECM) components such as collagen and elastic fibers. Disappearance of microfibrillar-associated protein 4 (MFAP-4), a possible limiting factor for cutaneous elasticity, was documented in photoaged dermis, but its function is poorly understood. To characterize its possible contribution to photoprotection, MFAP-4 expression was either augmented or inhibited in a human skin xenograft photodamage murine model and human fibroblasts. Xenografted skin with enhanced MFAP-4 expression was protected from UVB-induced photodamage/photoaging accompanied by the prevention of ECM degradation and aggravated elasticity. Additionally, remarkably increased or decreased fibrillin-1-based microfibril development was observed when fibroblasts were treated with recombinant MFAP-4 or with MFAP-4-specific siRNA, respectively. Immunoprecipitation analysis confirmed direct interaction between MFAP-4 and fibrillin-1. Taken together, our findings reveal the essential role of MFAP-4 in photoprotection and offer new therapeutic opportunities to prevent skin-associated pathologies."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep00164"xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Fujimura T."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Kobinger G.P."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Kitahara T."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Hachiya A."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Haketa K."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Kasamatsu S."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Takema Y."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Bello A."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Sriwiriyanont P."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Visscher M.O."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/author | "Kitzmiller W.J."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/pages | "164"xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/title | "Essential role of microfibrillar-associated protein 4 in human cutaneous homeostasis and in its photoprotection."xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/22355679 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22355679 |
| http://purl.uniprot.org/citations/22355679 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22355679 |
| http://purl.uniprot.org/uniprot/P55083#attribution-6436AA220FBEA7C20208A8E867864292 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22355679 |
| http://purl.uniprot.org/uniprot/#_P55083-mappedCitation-22355679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355679 |
| http://purl.uniprot.org/uniprot/#_P35555-mappedCitation-22355679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22355679 |
| http://purl.uniprot.org/uniprot/P35555 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22355679 |