| http://purl.uniprot.org/citations/22355704 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22355704 | http://www.w3.org/2000/01/rdf-schema#comment | "Cdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.org/dc/terms/identifier | "doi:10.1038/srep00189"xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Sacristan M.P."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Malumbres M."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Gomez-Lopez G."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Chiesa M."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Guillamot M."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Manchado E."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/author | "Pisano D.G."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/name | "Sci Rep"xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/pages | "189"xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/title | "Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription."xsd:string |
| http://purl.uniprot.org/citations/22355704 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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