| http://purl.uniprot.org/citations/22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22357756 | http://www.w3.org/2000/01/rdf-schema#comment | "Two mechanisms that play important roles in cell fate decisions are control of a "core transcriptional network" and repression of alternative transcriptional programs by antagonizing transcription factors. Whether these two mechanisms operate together is not known. Here we report that GATA-1, SCL, and Klf1 form an erythroid core transcriptional network by co-occupying >300 genes. Importantly, we find that PU.1, a negative regulator of terminal erythroid differentiation, is a highly integrated component of this network. GATA-1, SCL, and Klf1 act to promote, whereas PU.1 represses expression of many of the core network genes. PU.1 also represses the genes encoding GATA-1, SCL, Klf1, and important GATA-1 cofactors. Conversely, in addition to repressing PU.1 expression, GATA-1 also binds to and represses >100 PU.1 myelo-lymphoid gene targets in erythroid progenitors. Mathematical modeling further supports that this dual mechanism of repressing both the opposing upstream activator and its downstream targets provides a synergistic, robust mechanism for lineage specification. Taken together, these results amalgamate two key developmental principles, namely, regulation of a core transcriptional network and repression of an alternative transcriptional program, thereby enhancing our understanding of the mechanisms that establish cellular identity."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1121019109"xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Smith C."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Weissman S.M."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Skoultchi A.I."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Bergman A."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Snyder M.P."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Bresnick E.H."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "Wontakal S.N."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/author | "MacCarthy T."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/pages | "3832-3837"xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/title | "A core erythroid transcriptional network is repressed by a master regulator of myelo-lymphoid differentiation."xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22357756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22357756 |
| http://purl.uniprot.org/citations/22357756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22357756 |
| http://purl.uniprot.org/uniprot/#_E9QAI9-mappedCitation-22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357756 |
| http://purl.uniprot.org/uniprot/#_E9Q6W1-mappedCitation-22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357756 |
| http://purl.uniprot.org/uniprot/#_A0A6I8MWY6-mappedCitation-22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357756 |
| http://purl.uniprot.org/uniprot/#_A2AD40-mappedCitation-22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357756 |
| http://purl.uniprot.org/uniprot/#_B1AUB3-mappedCitation-22357756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357756 |