| http://purl.uniprot.org/citations/22357843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22357843 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1 receptor accessory protein (IL-1RAcP) is the essential component of receptor complexes mediating immune responses to interleukin-1 family cytokines. IL-1RAcP in the brain exists in two isoforms, IL-1RAcP and IL-1RAcPb, differing only in the C-terminal region. Here, we found robust synaptogenic activities of IL-1RAcP in cultured cortical neurons. Knockdown of IL-1RAcP isoforms in cultured cortical neurons suppressed synapse formation as indicated by decreases of active zone protein Bassoon puncta and dendritic protrusions. IL-1RAcP recovered the accumulation of presynaptic Bassoon puncta, while IL-1RAcPb rescued both Bassoon puncta and dendritic protrusions. Consistently, the expression of IL-1RAcP in cortical neurons enhances the accumulation of Bassoon puncta and that of IL-1RAcPb stimulated both Bassoon puncta accumulation and spinogenesis. IL-1RAcP interacted with protein tyrosine phosphatase (PTP) δ through the extracellular domain. Mini-exon peptides in the Ig-like domains of PTPδ splice variants were critical for their efficient binding to IL-1RAcP. The synaptogenic activities of IL-1RAcP isoforms were diminished in cortical neurons from PTPδ knock-out mice. Correspondingly, PTPδ required IL-1RAcPb to induce postsynaptic differentiation. Thus, IL-1RAcPb bidirectionally regulated synapse formation of cortical neurons. Furthermore, the spine densities of cortical and hippocampal pyramidal neurons were reduced in IL-1RAcP knock-out mice lacking both isoforms. These results suggest that IL-1RAcP isoforms function as trans-synaptic cell adhesion molecules in the brain and organize synapse formation. Thus, IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4637-11.2012"xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Lee S.J."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Uemura T."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Mishina M."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Shiroshima T."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/author | "Yasumura M."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/pages | "2588-2600"xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/title | "Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule."xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22357843 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22357843 |
| http://purl.uniprot.org/citations/22357843 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22357843 |
| http://purl.uniprot.org/uniprot/Q61730#attribution-54944790029B2C5E987B4F1DAAFB9FAC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22357843 |
| http://purl.uniprot.org/uniprot/Q64487#attribution-54944790029B2C5E987B4F1DAAFB9FAC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22357843 |
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| http://purl.uniprot.org/uniprot/#_E9Q7I7-mappedCitation-22357843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357843 |
| http://purl.uniprot.org/uniprot/#_O88737-mappedCitation-22357843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357843 |
| http://purl.uniprot.org/uniprot/#_G3UWK6-mappedCitation-22357843 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22357843 |