| http://purl.uniprot.org/citations/22358839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22358839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22358839 | http://www.w3.org/2000/01/rdf-schema#comment | "Packaging of proteins from the endoplasmic reticulum into COPII vesicles is essential for secretion. In cells, most COPII vesicles are approximately 60-80 nm in diameter, yet some must increase their size to accommodate 300-400 nm procollagen fibres or chylomicrons. Impaired COPII function results in collagen deposition defects, cranio-lenticulo-sutural dysplasia, or chylomicron retention disease, but mechanisms to enlarge COPII coats have remained elusive. Here, we identified the ubiquitin ligase CUL3-KLHL12 as a regulator of COPII coat formation. CUL3-KLHL12 catalyses the monoubiquitylation of the COPII-component SEC31 and drives the assembly of large COPII coats. As a result, ubiquitylation by CUL3-KLHL12 is essential for collagen export, yet less important for the transport of small cargo. We conclude that monoubiquitylation controls the size and function of a vesicle coat."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10822"xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10822"xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Jin L."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Schekman R."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Schekman R."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Rape M."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Rape M."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Wickliffe K.E."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Wickliffe K.E."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Baumgartel C."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Baumgartel C."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Gorur A."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Gorur A."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Pahuja K.B."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/author | "Pahuja K.B."xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/pages | "495-500"xsd:string |
| http://purl.uniprot.org/citations/22358839 | http://purl.uniprot.org/core/pages | "495-500"xsd:string |