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| http://purl.uniprot.org/citations/22359102 | http://www.w3.org/2000/01/rdf-schema#comment | "We have investigated the cytotoxicity in Saccharomyces cerevisiae of the novel antitumor agent 3-bromopyruvate (3-BP). 3-BP enters the yeast cells through the lactate/pyruvate H(+) symporter Jen1p and inhibits cell growth at minimal inhibitory concentration of 1.8 mM when grown on non-glucose conditions. It is not submitted to the efflux pumps conferring Pleiotropic Drug Resistance in yeast. Yeast growth is more sensitive to 3-BP than Gleevec (Imatinib methanesulfonate) which in contrast to 3-BP is submitted to the PDR network of efflux pumps. The sensitivity of yeast to 3-BP is increased considerably by mutations or chemical treatment by buthionine sulfoximine that decrease the intracellular concentration of glutathione."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10863-012-9421-8"xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Goffeau A."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Casal M."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Ulaszewski S."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Pedersen P.L."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Ko Y.H."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Zarzycki M."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/author | "Lis P."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/name | "J Bioenerg Biomembr"xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/pages | "155-161"xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/title | "Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/22359102 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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