| http://purl.uniprot.org/citations/22359676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22359676 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22359676 | http://www.w3.org/2000/01/rdf-schema#comment | "Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor. Bi-KTI showed no detectable inhibitory effect on factor Xa, thrombin, or tissue plasminogen activator. In contrast, Bi-KTI strongly inhibited plasmin, indicating that it acts as an antifibrinolytic agent; however, this inhibitory ability was two-fold weaker than that of aprotinin. The fibrin(ogen)olytic activities of B. ignitus venom serine protease (Bi-VSP) and plasmin in the presence of Bi-KTI indicate that Bi-KTI targets plasmin more specifically than Bi-VSP. These findings demonstrate a novel mechanism by which bumblebee venom affects the hemostatic system through the antifibrinolytic activity of Bi-KTI and through Bi-VSP-mediated fibrin(ogen)olytic activities, raising interest in Bi-KTI and Bi-VSP as potential clinical agents."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0032269"xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0032269"xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Lee K.S."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Qiu Y."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Jin B.R."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Jin B.R."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Yoon H.J."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Yoon H.J."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Wan H."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Wan H."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Sohn H.D."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Sohn H.D."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Choo Y.M."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Choo Y.M."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Sohn M.R."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/author | "Sohn M.R."xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/22359676 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |