| http://purl.uniprot.org/citations/22363008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22363008 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22363008 | http://www.w3.org/2000/01/rdf-schema#comment | "Death is a vital developmental cell fate. In Caenorhabditis elegans, programmed death of the linker cell, which leads gonadal elongation, proceeds independently of caspases and apoptotic effectors. To identify genes promoting linker-cell death, we performed a genome-wide RNA interference screen. We show that linker-cell death requires the gene pqn-41, encoding an endogenous polyglutamine-repeat protein. pqn-41 functions cell-autonomously and is expressed at the onset of linker-cell death. pqn-41 expression is controlled by the mitogen-activated protein kinase kinase SEK-1, which functions in parallel to the zinc-finger protein LIN-29 to promote cellular demise. Linker-cell death is morphologically similar to cell death associated with normal vertebrate development and polyglutamine-induced neurodegeneration. Our results may therefore provide molecular inroads to understanding nonapoptotic cell death in metazoan development and disease."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1215156"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1215156"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Shaham S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Yoshimura S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Abraham M.C."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Abraham M.C."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Blum E.S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/author | "Blum E.S."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/pages | "970-973"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/pages | "970-973"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/title | "Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/title | "Control of nonapoptotic developmental cell death in Caenorhabditis elegans by a polyglutamine-repeat protein."xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/volume | "335"xsd:string |
| http://purl.uniprot.org/citations/22363008 | http://purl.uniprot.org/core/volume | "335"xsd:string |