| http://purl.uniprot.org/citations/22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22364200 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of melanocortin peptide agonists to the melanocortin-1 receptor of melanocytes results in eumelanin production, whereas binding of the agouti signalling protein inverse agonist results in pheomelanin synthesis. Recently, a novel melanocortin-1 receptor ligand was reported. A β-defensin gene mutation was found to be responsible for black coat colour in domestic dogs. Notably, the human equivalent, β-defensin 3, was found to bind with high affinity to the melanocortin-1 receptor; however, the action of β-defensin as an agonist or antagonist was unknown. Here, we use in vitro assays to show that β-defensin 3 is able to act as a weak partial agonist for cAMP signalling in human embryonic kidney (HEK) cells expressing human melanocortin-1 receptor. β-defensin 3 is also able to activate MAPK signalling in HEK cells stably expressing either wild type or variant melanocortin-1 receptors. We suggest that β-defensin 3 may be a novel melanocortin-1 receptor agonist involved in regulating melanocyte responses in humans."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1755-148x.2012.00990.x"xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Alewood P.F."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Liu Y.Y."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Smith J.J."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Millhauser G.L."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Patel M.P."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Sturm R.A."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Beaumont K.A."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Smit D.J."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/author | "Chai E."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/name | "Pigment Cell Melanoma Res"xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/pages | "370-374"xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/title | "Melanocortin-1 receptor-mediated signalling pathways activated by NDP-MSH and HBD3 ligands."xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/22364200 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22364200 |
| http://purl.uniprot.org/citations/22364200 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22364200 |
| http://purl.uniprot.org/uniprot/#_Q1JUM0-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |
| http://purl.uniprot.org/uniprot/#_Q1JUM2-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |
| http://purl.uniprot.org/uniprot/#_Q1JUM3-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |
| http://purl.uniprot.org/uniprot/#_Q1JUM4-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |
| http://purl.uniprot.org/uniprot/#_Q1JUM5-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |
| http://purl.uniprot.org/uniprot/#_A0A894JZ42-mappedCitation-22364200 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22364200 |