| http://purl.uniprot.org/citations/22365665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22365665 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-1β (IL-1β) is a potent inflammatory cytokine that is usually cleaved and activated by inflammasome-associated caspase-1. To determine whether IL-1β activation is regulated by inhibitor of apoptosis (IAP) proteins, we treated macrophages with an IAP-antagonist "Smac mimetic" compound or genetically deleted the genes that encode the three IAP family members cIAP1, cIAP2, and XIAP. After Toll-like receptor priming, IAP inhibition triggered cleavage of IL-1β that was mediated not only by the NLRP3-caspase-1 inflammasome, but also by caspase-8 in a caspase-1-independent manner. In the absence of IAPs, rapid and full generation of active IL-1β by the NLRP3-caspase-1 inflammasome, or by caspase-8, required the kinase RIP3 and reactive oxygen species production. These results demonstrate that activation of the cell death-inducing ripoptosome platform and RIP3 can generate bioactive IL-1β and implicate them as additional targets for the treatment of pathological IL-1-driven inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.01.012"xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "O'Reilly L."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Wong W.W."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Gross O."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Vince J.E."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Castillo R."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Guarda G."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Lawlor K.E."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Silke J."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Mason K."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Anderton H."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Gentle I."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Allam R."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/author | "Hacker G."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/pages | "215-227"xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/title | "Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation."xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/22365665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22365665 |
| http://purl.uniprot.org/citations/22365665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22365665 |