| http://purl.uniprot.org/citations/22365829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22365829 | http://www.w3.org/2000/01/rdf-schema#comment | "Cell cycle-dependent expression of canonical histone proteins enables newly synthesized DNA to be integrated into chromatin in replicating cells. However, the molecular basis of cell cycle-dependency in the switching of histone gene regulation remains to be uncovered. Here, we report the identification and biochemical characterization of a molecular switcher, HERS (histone gene-specific epigenetic repressor in late S phase), for nucleosomal core histone gene inactivation in Drosophila. HERS protein is phosphorylated by a cyclin-dependent kinase (Cdk) at the end of S-phase. Phosphorylated HERS binds to histone gene regulatory regions and anchors HP1 and Su(var)3-9 to induce chromatin inactivation through histone H3 lysine 9 methylation. These findings illustrate a salient molecular switch linking epigenetic gene silencing to cell cycle-dependent histone production."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.12.029"xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Tanabe M."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Ito S."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Kato S."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Lim J."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Miki T."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Murata T."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Ueda T."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Fujiki R."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Ohtake F."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Sawatsubashi S."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Takeyama K."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Fujiyama-Nakamura S."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Shiozaki-Sato Y."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Kamoshida Y."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/author | "Kouzmenko A."xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/pages | "494-504"xsd:string |
| http://purl.uniprot.org/citations/22365829 | http://purl.uniprot.org/core/title | "Epigenetic silencing of core histone genes by HERS in Drosophila."xsd:string |