| http://purl.uniprot.org/citations/22366453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22366453 | http://www.w3.org/2000/01/rdf-schema#comment | "CIZ1 is a nuclear-matrix-associated DNA replication factor unique to higher eukaryotes, for which alternatively spliced isoforms have been associated with a range of disorders. In vitro, the CIZ1 N-terminus interacts with cyclin E and cyclin A at distinct sites, enabling functional cooperation with cyclin-A-Cdk2 to promote replication initiation. C-terminal sequences anchor CIZ1 to fixed sites on the nuclear matrix, imposing spatial constraint on cyclin-dependent kinase activity. Here we demonstrate that CIZ1 is predominantly expressed as a predicted full-length product throughout mouse development, consistent with a ubiquitous role in cell and tissue renewal. CIZ1 is expressed in proliferating stem cells of the testis, but is notably downregulated following commitment to differentiation. Significantly, CIZ1 is re-expressed at high levels in non-proliferative spermatocytes before meiotic division. Sequence analysis identifies at least seven alternatively spliced variants, including a dominant cancer-associated form and a set of novel isoforms. Furthermore, we show that in these post-replicative cells, CIZ1 interacts with germ-cell-specific cyclin A1, which has been implicated in the repair of DNA double-strand breaks. Consistent with this role, antibody depletion of CIZ1 reduces the capacity for testis extract to repair digested plasmid DNA in vitro. Together, the data imply post-replicative roles for CIZ1 in germ cell differentiation that might include meiotic recombination - a process intrinsic to genome stability and diversification."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.101097"xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/author | "Ainscough J.F."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/author | "Coverley D."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/author | "Copeland N.A."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/author | "Greaves E.A."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/pages | "2466-2477"xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/title | "Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells."xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://purl.uniprot.org/core/volume | "125"xsd:string |
| http://purl.uniprot.org/citations/22366453 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22366453 |
| http://purl.uniprot.org/citations/22366453 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22366453 |
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| http://purl.uniprot.org/uniprot/#_A0A0A0MQJ7-mappedCitation-22366453 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22366453 |
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