| http://purl.uniprot.org/citations/22377328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22377328 | http://www.w3.org/2000/01/rdf-schema#comment | "Medial hypertrophy of pulmonary arterioles during pulmonary arterial hypertension (PAH) in humans is associated with enhanced proliferation of smooth muscle cells (SMCs). Elevated matrix metalloproteinase (MMP)-2 has been found in pulmonary artery SMCs (PA-SMCs) in humans with idiopathic PAH, leading to the hypothesis that MMP-2 contributes to the proliferation and migration of vascular SMCs in the pathogenesis of PAH. Rapidly growing meat-type (broiler) chickens provide a model of spontaneous PAH. The present study was conducted to determine whether MMP-2 is involved in the medial hypertrophy of pulmonary arterioles in this model. Cultured PA-SMCs from normal birds were used to evaluate the effect of MMPs on cell proliferation. Gelatin zymography showed that endothelin (ET)-1-induced proliferation of PA-SMCs was concomitant with increased pro- and active MMP-2 production. Reverse transcription PCR demonstrated upregulation of MMP-2 mRNA. However, PA-SMC proliferation was inhibited by the MMP inhibitors doxycycline and cis-9-octadecenoyl-N-hydroxylamide. In vivo experiments revealed a significant increase of MMP-2 expression in hypertrophied pulmonary arterioles of PAH broiler chickens, which was positively correlated with wall thickness and medial hypertrophy. MMP-2 may contribute to medial hypertrophy in pulmonary arterioles during PAH in broiler chickens by enhancing the proliferation of vascular SMCs."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tvjl.2012.01.017"xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Zhou J.Y."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Chai J."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Li J.J."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Li W.W."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/author | "Bi S.C."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/name | "Vet J"xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/pages | "420-425"xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/title | "Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension."xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://purl.uniprot.org/core/volume | "193"xsd:string |
| http://purl.uniprot.org/citations/22377328 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22377328 |
| http://purl.uniprot.org/citations/22377328 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22377328 |
| http://purl.uniprot.org/uniprot/#_Q90611-mappedCitation-22377328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22377328 |
| http://purl.uniprot.org/uniprot/Q90611 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22377328 |