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http://purl.uniprot.org/citations/22377528http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22377528http://www.w3.org/2000/01/rdf-schema#comment"

Background

Fetuin-A is a hepatic secretory protein that inhibits arterial calcification in vitro. The association of fetuin-A with coronary arterial calcification (CAC) in the general population is uncertain.

Methods

Among 2457 community-living individuals without cardiovascular disease (CVD), we measured serum fetuin-A concentrations by ELISA and evaluated the cross-sectional association of fetuin-A with CAC prevalence (any vs none) and severity; on follow-up 3.2 years (median) later, we evaluated the association of fetuin-A with CAC incidence and progression.

Results

The mean age was 62 (SD 10) years, and the mean fetuin-A concentration was 0.48 (0.10) g/L. At baseline, 1200 individuals (49%) had CAC, and 272 individuals developed CAC during follow-up. At baseline, there was a threshold effect at the lowest fetuin-A quartile with CAC prevalence. In models adjusted for demographics, traditional cardiovascular disease (CVD) risk factors and kidney function, the lowest fetuin-A quartile had 7% (95% CI 1%-13%; P = 0.04) greater CAC prevalence compared with quartiles 2-4. Similar associations were observed with CAC severity at baseline, but the association was more linear. Each SD (0.10 g/L) lower fetuin-A was associated with a 12% (95% CI 3%-21%; P = 0.01) greater CAC severity in adjusted models. There was no significant association of fetuin-A with CAC incidence or progression.

Conclusions

Fetuin-A is inversely associated with CAC severity among community-living individuals without CVD. Whether fetuin-A concentrations are associated with incident CVD event in the general population requires future study."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.org/dc/terms/identifier"doi:10.1373/clinchem.2011.177725"xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Peralta C.A."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Shlipak M.G."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"de Boer I.H."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Siscovick D."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Katz R."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Jenny N.S."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Criqui M.H."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Ix J.H."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Allison M.A."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Budoff M."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/author"Kestenbaum B.R."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/name"Clin Chem"xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/pages"887-895"xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/title"Fetuin-A is inversely associated with coronary artery calcification in community-living persons: the Multi-Ethnic Study of Atherosclerosis."xsd:string
http://purl.uniprot.org/citations/22377528http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/22377528http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22377528
http://purl.uniprot.org/citations/22377528http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22377528
http://purl.uniprot.org/uniprot/#_B7Z556-mappedCitation-22377528http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22377528
http://purl.uniprot.org/uniprot/#_B7Z8Q2-mappedCitation-22377528http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22377528
http://purl.uniprot.org/uniprot/#_P02765-mappedCitation-22377528http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22377528
http://purl.uniprot.org/uniprot/P02765http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22377528
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