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http://purl.uniprot.org/citations/22379998http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22379998http://www.w3.org/2000/01/rdf-schema#comment"

Aims

An association between carbamazepine-induced hypersensitivity and HLA-A*3101 has been reported in populations of both European and Asian descent. We aimed to investigate HLA-A*3101 and other common variants across the genome as markers for cutaneous adverse drug reactions (cADRs) attributed to lamotrigine and phenytoin.

Materials & methods

We recruited patients with lamotrigine-induced cADRs (n = 46) and patients with phenytoin-cADRs (n = 44) and the 1958 British birth cohort was used as a control (n = 1296). HLA-A*3101 was imputed from genome-wide association study data. We applied genome-wide association to study lamotrigine- and phenytoin-induced cADR, and total cADR cases combined.

Results

Neither HLA-A*3101 nor any other genetic marker significantly predicted lamotrigine- or phenytoin-induced cADRs.

Conclusion

HLA-A*3101 does not appear to be a predictor for lamotrigine- and phenytoin-induced cADRs in Europeans. Our genome-wide association study results do not support the existence of a clinically relevant common variant for the development of lamotrigine- or phenytoin-induced cADRs. As a predictive marker, HLA-A*3101 appears to be specific for carbamazepine-induced cADRs."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.org/dc/terms/identifier"doi:10.2217/pgs.11.165"xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Depondt C."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Heinzen E.L."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Pandolfo M."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Delanty N."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Shianna K.V."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Sisodiya S.M."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Kasperaviciute D."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"McCormack M."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Cavalleri G.L."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Chaila E."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Radtke R.A."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Walley N."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"Urban T.J."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/author"O'Conner G.D."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/name"Pharmacogenomics"xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/pages"399-405"xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/title"Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions."xsd:string
http://purl.uniprot.org/citations/22379998http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/22379998http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22379998
http://purl.uniprot.org/citations/22379998http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22379998
http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-22379998http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22379998
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