| http://purl.uniprot.org/citations/22382019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22382019 | http://www.w3.org/2000/01/rdf-schema#comment | "Smads are intracellular signaling mediators. Complexes of Smad2 and Smad3 with Smad4 transmit transforming growth factor-beta (TGF-β) receptor-induced signaling. Snail plays important roles in mesoderm formation, gastrulation, neural crest development, and epithelial mesenchymal transition. However, it remains unknown whether Smad3 and Snail expression is circadian rhythm-dependent. Here, we showed for the first time that Smad3 and Snail show circadian expression in human gingival fibroblasts (HGF-1) and human mesenchymal stem cells (MSC) after serum shock. They also showed circadian expression in the mouse liver. We confirmed that BMAL1/2, DEC1/2, VEGF, and PER1/2/3 also show circadian expression in both HGF-1 and MSC. The mRNA peaks and phases in circadian expression of these genes differed between HGF-1 and MSC. In a luciferase assay, Smad3 promoter activity was upregulated by CLOCK/BMAL1. These findings suggest that Smad3 and Snail have circadian rhythm in vitro and vivo, and that circadian expression of Smad3 depends on CLOCK/BMAL1."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.02.076"xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Kawamoto T."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Kato Y."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Sato F."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Sato H."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Seino H."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Fujimoto K."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Kijima H."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Jin D."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Noshiro M."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Bhawal U.K."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/author | "Morohashi S."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/pages | "441-446"xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/title | "Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver."xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://purl.uniprot.org/core/volume | "419"xsd:string |
| http://purl.uniprot.org/citations/22382019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22382019 |
| http://purl.uniprot.org/citations/22382019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22382019 |
| http://purl.uniprot.org/uniprot/#_B7Z725-mappedCitation-22382019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22382019 |
| http://purl.uniprot.org/uniprot/#_Q02085-mappedCitation-22382019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22382019 |
| http://purl.uniprot.org/uniprot/#_Q05CN3-mappedCitation-22382019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22382019 |