| http://purl.uniprot.org/citations/22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22386268 | http://www.w3.org/2000/01/rdf-schema#comment | "Neutralizing antibodies have been thought to be required for protection against acutely cytopathic viruses, such as the neurotropic vesicular stomatitis virus (VSV). Utilizing mice that possess B cells but lack antibodies, we show here that survival upon subcutaneous (s.c.) VSV challenge was independent of neutralizing antibody production or cell-mediated adaptive immunity. However, B cells were absolutely required to provide lymphotoxin (LT) α1β2, which maintained a protective subcapsular sinus (SCS) macrophage phenotype within virus draining lymph nodes (LNs). Macrophages within the SCS of B cell-deficient LNs, or of mice that lack LTα1β2 selectively in B cells, displayed an aberrant phenotype, failed to replicate VSV, and therefore did not produce type I interferons, which were required to prevent fatal VSV invasion of intranodal nerves. Thus, although B cells are essential for survival during VSV infection, their contribution involves the provision of innate differentiation and maintenance signals to macrophages, rather than adaptive immune mechanisms."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.01.013"xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Fu Y.X."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Hacohen N."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "von Andrian U.H."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Chevrier N."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Tumanov A."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Moseman E.A."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Iannacone M."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Tonti E."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/author | "Bosurgi L."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/pages | "415-426"xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/title | "B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/22386268 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22386268 |
| http://purl.uniprot.org/citations/22386268 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22386268 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |
| http://purl.uniprot.org/uniprot/#_A0A0X1KG58-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |
| http://purl.uniprot.org/uniprot/#_A0A0U5JAA2-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |
| http://purl.uniprot.org/uniprot/#_A4FUI4-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |
| http://purl.uniprot.org/uniprot/#_G3V002-mappedCitation-22386268 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22386268 |