| http://purl.uniprot.org/citations/22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22387002 | http://www.w3.org/2000/01/rdf-schema#comment | "The placenta is a hematopoietic organ that supports hematopoietic stem/progenitor cell (HSPC) generation and expansion without promoting differentiation. We identified PDGF-B signaling in trophoblasts as a key component of the unique placental hematopoietic microenvironment that protects HSPCs from premature differentiation. Loss of PDGF-B or its receptor, PDGFRβ, induced definitive erythropoiesis in placental labyrinth vasculature. This was evidenced by accumulation of CFU-Es and actively proliferating definitive erythroblasts that clustered around central macrophages, highly reminiscent of erythropoiesis in the fetal liver. Ectopic erythropoiesis was not due to a requirement of PDGF-B signaling in hematopoietic cells but rather in placental trophoblasts, which upregulated Epo in the absence of PDGF-B signaling. Furthermore, overexpression of hEPO specifically in the trophoblasts in vivo was sufficient to convert the placenta into an erythropoietic organ. These data provide genetic evidence of a signaling pathway that is required to restrict erythroid differentiation to specific anatomical niches during development."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.12.022"xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Chhabra A."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Acharya A."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Ueno M."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Mikkola H.K."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Iruela-Arispe M.L."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Tallquist M.D."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Lechner A.J."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/author | "Van Handel B."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/pages | "651-659"xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/title | "Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling."xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/22387002 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22387002 |
| http://purl.uniprot.org/citations/22387002 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YX84-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1E6-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1G1-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1M6-mappedCitation-22387002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22387002 |