| http://purl.uniprot.org/citations/22388350 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22388350 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of the E3 ubiquitin ligase murine double minute 2 (Mdm2) in regulating the stability of the p53 tumor suppressor is well documented. By contrast, relatively little is known about p53-independent activities of Mdm2 and the role of Mdm2 in cellular differentiation. Here we report a novel role for Mdm2 in the initiation of adipocyte differentiation that is independent of its ability to regulate p53. We show that Mdm2 is required for cAMP-mediated induction of CCAAT/enhancer-binding protein δ (C/EBPδ) expression by facilitating recruitment of the cAMP regulatory element-binding protein (CREB) coactivator, CREB-regulated transcription coactivator (Crtc2)/TORC2, to the c/ebpδ promoter. Our findings reveal an unexpected role for Mdm2 in the regulation of CREB-dependent transactivation during the initiation of adipogenesis. As Mdm2 is able to promote adipogenesis in the myoblast cell line C2C12, it is conceivable that Mdm2 acts as a switch in cell fate determination."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2012.15"xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Akimov V."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Blagoev B."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Olson M.V."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Madsen L."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Kristiansen K."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Marine J.C."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Petersen R.K."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Cinti S."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Murano I."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Lozano G."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Feddersen S."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Hallenborg P."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Gjertsen B.T."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Francoz S."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/author | "Sundekilde U."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/pages | "1381-1389"xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/title | "Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22388350 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22388350 |
| http://purl.uniprot.org/citations/22388350 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22388350 |