| http://purl.uniprot.org/citations/22388351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22388351 | http://www.w3.org/2000/01/rdf-schema#comment | "BTBD10, an Akt interactor, activates Akt by decreasing the protein phosphatase 2A-mediated dephosphorylation and inactivation of Akt. Overexpression of BTBD10 suppresses motor neuron death that is induced by a familial amyotrophic lateral sclerosis (ALS)-linked superoxide dismutase 1 (SOD1) mutant, G93A-SOD1 in vitro. In this study, we further investigated the BTBD10-mediated suppression of motor neuron death. We found that the small interfering RNA-mediated inhibition of BTBD10 expression led to the death of cultured motor neurons. In Caenorhabditis elegans (C. elegans), disruption of the btbd-10 gene caused not only loss of neurons, including both motor and touch-receptor neurons, but also a locomotion defect. In addition, we found that the expression of BTBD10 was generally decreased in the motor neurons from patients of sporadic ALS and transgenic mice overexpressing G93A-SOD1 (G93A-SOD1-transgenic mice). Collectively, these results suggest that the reduced expression of BTBD10 leads to motor neuron death both in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.org/dc/terms/identifier | "doi:10.1038/cdd.2012.19"xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Okamoto K."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Matsuoka M."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Kage-Nakadai E."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Aiso S."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/author | "Nawa M."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/pages | "1398-1407"xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/title | "Reduced expression of BTBD10, an Akt activator, leads to motor neuron death."xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22388351 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22388351 |
| http://purl.uniprot.org/citations/22388351 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22388351 |
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