| http://purl.uniprot.org/citations/22388736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22388736 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22388736 | http://www.w3.org/2000/01/rdf-schema#comment | "The ASAP complex interacts with the exon-junction complex (EJC), a messenger ribonucleoprotein complex involved in post-transcriptional regulation. The three ASAP subunits (Acinus, RNPS1 and SAP18) have been individually implicated in transcriptional regulation, pre-mRNA splicing and mRNA quality control. To shed light on the basis for and consequences of ASAP's interaction with the EJC, we have determined the 1.9-Å resolution structure of a eukaryotic ASAP core complex. The RNA-recognition motif of RNPS1 binds to a conserved motif of Acinus with a recognition mode similar to that observed in splicing U2AF proteins. The Acinus-RNPS1 platform recruits the ubiquitin-like domain of SAP18, forming a ternary complex that has both RNA- and protein-binding properties. Unexpectedly, our structural analysis identified an Acinus-like motif in Pinin, another EJC-associated splicing factor. We show that Pinin physically interacts with RNPS1 and SAP18, forming an alternative ternary complex, PSAP."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2242"xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.2242"xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Conti E."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Conti E."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Ebert J."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Ebert J."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Basquin C."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Basquin C."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Le Hir H."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Le Hir H."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Murachelli A.G."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/author | "Murachelli A.G."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/pages | "378-386"xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/pages | "378-386"xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/title | "The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/title | "The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex."xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/22388736 | http://purl.uniprot.org/core/volume | "19"xsd:string |