| http://purl.uniprot.org/citations/22391037 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22391037 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular morphogenesis, including polarized outgrowth, promotes tissue shape and function. Polarized vesicle trafficking has emerged as a fundamental mechanism by which protein and membrane can be targeted to discrete subcellular domains to promote localized protrusions. Frizzled (Fz)/planar cell polarity (PCP) signaling orchestrates cytoskeletal polarization and drives morphogenetic changes in such contexts as the vertebrate body axis and external Drosophila melanogaster tissues. Although regulation of Fz/PCP signaling via vesicle trafficking has been identified, the interplay between the vesicle trafficking machinery and downstream terminal PCP-directed processes is less established. In this paper, we show that Drosophila CK1-γ/gilgamesh (gish) regulates the PCP-associated process of trichome formation through effects on Rab11-mediated vesicle recycling. Although the core Fz/PCP proteins dictate prehair formation broadly, CK1-γ/gish restricts nucleation to a single site. Moreover, CK1-γ/gish works in parallel with the Fz/PCP effector multiple wing hairs, which restricts prehair formation along the perpendicular axis to Gish. Our findings suggest that polarized Rab11-mediated vesicle trafficking regulated by CK1-γ is required for PCP-directed processes."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201107137"xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/author | "Weber U."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/author | "Olguin P."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/author | "Gault W.J."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/pages | "605-621"xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/title | "Drosophila CK1-gamma, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking."xsd:string |
| http://purl.uniprot.org/citations/22391037 | http://purl.uniprot.org/core/volume | "196"xsd:string |
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