| http://purl.uniprot.org/citations/22391484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22391484 | http://www.w3.org/2000/01/rdf-schema#comment | "Planar cell polarity (PCP) is a common feature of many epithelia and epithelial organs. Although progress has been made in the dissection of molecular mechanisms regulating PCP, many questions remain. Here we describe a screen to identify novel PCP regulators in Drosophila. We employed mild gain-of-function (GOF) phenotypes of two cytoplasmic Frizzled (Fz)/PCP core components, Diego (Dgo) and Prickle (Pk), and screened these against the DrosDel genome-wide deficiency collection for dominant modifiers. Positive genomic regions were rescreened and narrowed down with smaller overlapping deficiencies from the Exelixis collection and RNAi-mediated knockdown applied to individual genes. This approach isolated new regulators of PCP, which were confirmed with loss-of-function analyses displaying PCP defects in the eye and/or wing. Furthermore, knockdown of a subset was also sensitive to dgo dosage or dominantly modified a dishevelled (dsh) GOF phenotype, supporting a role in Fz/PCP-mediated polarity establishment. Among the new "PCP" genes we identified several kinases, enzymes required for lipid modification, scaffolding proteins, and genes involved in substrate modification and/or degradation. Interestingly, one of them is a member of the Meckel-Gruber syndrome factors, associated with human ciliopathies, suggesting an important role for cell polarity in nonciliated cells."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.111.137190"xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/author | "Mlodzik M."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/author | "Weber U."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/author | "Serysheva E."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/author | "Olguin P."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/author | "Gault W.J."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/pages | "145-162"xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/title | "Novel regulators of planar cell polarity: a genetic analysis in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/22391484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22391484 |
| http://purl.uniprot.org/citations/22391484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22391484 |
| http://purl.uniprot.org/uniprot/P10041#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/A1Z6W3#attribution-52FBF2A7C3951C80F7828F6FDD2366F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/Q01842#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/Q9V5N8#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/Q7JUF2#attribution-52FBF2A7C3951C80F7828F6FDD2366F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/Q8MRA6#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/A0A0B4KHL4#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/A0A4D6K823#attribution-522CFE97AB6263274CF55D28FFE7222D | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFQ6-mappedCitation-22391484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22391484 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KG15-mappedCitation-22391484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22391484 |