| http://purl.uniprot.org/citations/22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22399296 | http://www.w3.org/2000/01/rdf-schema#comment | "Estrogen receptor (ER) α promotes breast cancer growth by regulating gene expression through classical estrogen response element (ERE) binding and nonclassical (interaction with c-Jun at AP-1 sites) pathways. ER is the target for anti-estrogens such as tamoxifen (TAM). However, the potential for classical versus nonclassical ER signaling to influence hormone sensitivity is not known. Moreover, anti-estrogens frequently activate several signaling cascades besides the target ER, and the implications of these "off-target" signaling events have not been explored. Here, we report that p38γ MAPK is selectively activated by treatment with TAM. This results in both phosphorylation of ER at Ser-118 and stimulation of c-Jun transcription, thus switching ER signaling from the classical to the nonclassical pathway leading to increased hormone sensitivity. Unexpectedly, phosphorylation at Ser-118 is required for ER to bind both p38γ and c-Jun, thereby promoting ER relocation from ERE to AP-1 promoter sites. Thus, ER/Ser-118 phosphorylation serves as a central mechanism by which p38γ regulates signaling transduction of ER with its inhibitor TAM."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.349357"xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Chen G."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Huang J."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Wang P."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Zhi H."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Myers C.R."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Chitambar C.R."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Basir Z."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/author | "Lepp A."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/pages | "14681-14691"xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/title | "p38gamma mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription."xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22399296 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22399296 |
| http://purl.uniprot.org/citations/22399296 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22399296 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |
| http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW2-mappedCitation-22399296 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22399296 |