DESCRIBE <http://purl.uniprot.org/citations/22399610>

Subject	Predicate	Object
http://purl.uniprot.org/citations/22399610	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22399610	http://www.w3.org/2000/01/rdf-schema#comment	" Background/aim The role of cathepsin-D is well established in breast cancer progression, being correlated with worse clinical outcomes. However, to our knowledge, no study has been performed investigating its expression in primary breast cancer tumors and their corresponding recurrences or metastasis. Materials and methods Tissue sections from ten breast cancer cases and their corresponding local recurrences and six breast cancer cases and their corresponding metastases were immunohistochemically assessed for cathepsin-D reactivity. Cases diagnosed as either ductal carcinoma in situ (n=7), or breast carcinoma with no evidence of local recurrence or metastasis during follow-up (n=8) served as controls. Results Cathepsin-D was significantly up-regulated in all the study groups compared to controls. No difference was found between primary tumors and their corresponding recurrences or metastases. Conclusion Cathepsin-D-expressing breast cancer cells seem to be involved in local recurrence or metastasis formation. Large series are needed to further verify this result with the aim of possible future molecular intervention."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Kuhn C."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Friese K."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Dian D."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Shabani N."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Makrigiannakis A."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Jeschke U."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Vrekoussis T."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Mylonas I."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Schindlbeck C."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/author	"Navrozoglou I."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/date	"2012"xsd:gYear
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/name	"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/pages	"901-905"xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/title	"Expression of cathepsin-D in primary breast cancer and corresponding local recurrence or metastasis: an immunohistochemical study."xsd:string
http://purl.uniprot.org/citations/22399610	http://purl.uniprot.org/core/volume	"32"xsd:string
http://purl.uniprot.org/citations/22399610	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/22399610
http://purl.uniprot.org/citations/22399610	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/22399610
http://purl.uniprot.org/uniprot/#_A0A0S2Z3L4-mappedCitation-22399610	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22399610
http://purl.uniprot.org/uniprot/#_P07339-mappedCitation-22399610	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22399610
http://purl.uniprot.org/uniprot/#_V9HWI3-mappedCitation-22399610	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/22399610
http://purl.uniprot.org/uniprot/P07339	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22399610
http://purl.uniprot.org/uniprot/V9HWI3	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22399610
http://purl.uniprot.org/uniprot/A0A0S2Z3L4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/22399610