| http://purl.uniprot.org/citations/22405001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22405001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22405001 | http://www.w3.org/2000/01/rdf-schema#comment | "The endosomal sorting complexes required for transport (ESCRTs) facilitate endosomal sorting of ubiquitinated cargo, MVB biogenesis, late stages of cytokinesis, and retroviral budding. Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37. The X-ray crystal structure of the C-terminal region of UBAP1 reveals a domain that we describe as a solenoid of overlapping UBAs (SOUBA). NMR analysis shows that each of the three rigidly arranged overlapping UBAs making up the SOUBA interact with ubiquitin. We demonstrate that UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins, such as tetherin (BST-2/CD317), by viral countermeasures, namely, the HIV-1 accessory protein Vpu and the Kaposi sarcoma-associated herpesvirus (KSHV) ubiquitin ligase K5."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2011.12.013"xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2011.12.013"xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Freund S.M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Freund S.M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Williams R.L."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Williams R.L."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Allen M.D."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Allen M.D."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Bycroft M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Bycroft M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Agromayor M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Agromayor M."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Ye Y."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Hofmann K."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Soler N."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Soler N."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Perisic O."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Perisic O."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |
| http://purl.uniprot.org/citations/22405001 | http://purl.uniprot.org/core/author | "Martin-Serrano J."xsd:string |