| http://purl.uniprot.org/citations/22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22405012 | http://www.w3.org/2000/01/rdf-schema#comment | "The eukaryotic origin recognition complex (ORC) interacts with and remodels origins of DNA replication prior to initiation in S phase. Here, we report a single-particle cryo-EM-derived structure of the supramolecular assembly comprising Saccharomyces cerevisiae ORC, the replication initiation factor Cdc6, and double-stranded ARS1 origin DNA in the presence of ATPγS. The six subunits of ORC are arranged as Orc1:Orc4:Orc5:Orc2:Orc3, with Orc6 binding to Orc2. Cdc6 binding changes the conformation of ORC, in particular reorienting the Orc1 N-terminal BAH domain. Segmentation of the 3D map of ORC-Cdc6 on DNA and docking with the crystal structure of the homologous archaeal Orc1/Cdc6 protein suggest an origin DNA binding model in which the DNA tracks along the interior surface of the crescent-like ORC. Thus, ORC bends and wraps the DNA. This model is consistent with the observation that binding of a single Cdc6 extends the ORC footprint on origin DNA from both ends."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2012.01.011"xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Sun J."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Kawakami H."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Stillman B."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Speck C."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/author | "Zech J."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/pages | "534-544"xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/title | "Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy."xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/22405012 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22405012 |
| http://purl.uniprot.org/citations/22405012 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22405012 |
| http://purl.uniprot.org/uniprot/#_O43913-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_O43929-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P09119-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P50874-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P32833-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P38826-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P54784-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_P54790-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |
| http://purl.uniprot.org/uniprot/#_Q13415-mappedCitation-22405012 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22405012 |