| http://purl.uniprot.org/citations/22406270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22406270 | http://www.w3.org/2000/01/rdf-schema#comment | "IgE antibodies may be protective in parasite immunity, but their aberrant production can lead to allergic disease and life-threatening anaphylaxis. Despite the importance of IgE regulation, few studies have directly examined the B cells that express IgE, because these cells are rare and difficult to detect. Here, we describe fluorescent IgE reporter mice and validate a flow cytometry procedure to allow sensitive and specific identification of IgE-expressing B cells in vivo. Similar to IgG1(+) cells, IgE(+) B cells differentiated into germinal center (GC) B cells and plasma cells (PCs) during primary immune responses to a T cell-dependent hapten-protein conjugate and the helminth Nippostrongylus brasiliensis. However, the participation of IgE(+) B cells in GCs was transient. IgE(+) B cells had an atypical propensity to upregulate the transcription factor Blimp-1 and undergo PC differentiation. Most IgE(+) PCs were short lived and showed reduced affinity maturation, revealing intrinsic mechanisms that restrict the IgE antibody response."xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.02.009"xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/author | "Sullivan B.M."xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/author | "Allen C.D."xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/pages | "857-872"xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/title | "Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition."xsd:string |
| http://purl.uniprot.org/citations/22406270 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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