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| http://purl.uniprot.org/citations/22406641 | http://www.w3.org/2000/01/rdf-schema#comment | "Restoration of regulated insulin secretion is the ultimate goal of therapy for type 1 diabetes. Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express markers of mature β cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas. Lineage tracing experiments showed that gut Ins(+) cells arise cell autonomously from Foxo1-deficient cells. Inducible Foxo1 ablation in adult mice also resulted in the generation of gut Ins(+) cells. Following ablation by the β-cell toxin streptozotocin, gut Ins(+) cells regenerate and produce insulin, reversing hyperglycemia in mice. The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.2215"xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/author | "Kitamura T."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/author | "DePinho R.A."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/author | "Accili D."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/author | "Xuan S."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/author | "Talchai C."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/name | "Nat Genet"xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/pages | "406-412"xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/title | "Generation of functional insulin-producing cells in the gut by Foxo1 ablation."xsd:string |
| http://purl.uniprot.org/citations/22406641 | http://purl.uniprot.org/core/volume | "44"xsd:string |
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