| http://purl.uniprot.org/citations/22411803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22411803 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt binding to members of the seven-span transmembrane Frizzled (Fz) receptor family controls essential cell fate decisions and tissue polarity during development and in adulthood. The Fz-mediated membrane recruitment of the cytoplasmic effector Dishevelled (Dvl) is a critical step in Wnt/β-catenin signaling initiation, but how Fz and Dvl act together to drive downstream signaling events remains largely undefined. Here, we use an Fz peptide-based microarray to uncover a mechanistically important role of the bipartite Dvl DEP domain and C terminal region (DEP-C) in binding a three-segmented discontinuous motif in Fz. We show that cooperative use of two conserved motifs in the third intracellular loop and the classic C-terminal motif of Fz is required for DEP-C binding and Wnt-induced β-catenin activation in cultured cells and Xenopus embryos. Within the complex, the Dvl DEP domain mainly binds the Fz C-terminal tail, whereas a short region at the Dvl C-terminal end is required to bind the Fz third loop and stabilize the Fz-Dvl interaction. We conclude that Dvl DEP-C binding to Fz is a key event in Wnt-mediated signaling relay to β-catenin. The discontinuous nature of the Fz-Dvl interface may allow for precise regulation of the interaction in the control of Wnt-dependent cellular responses."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1114802109"xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Schambony A."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Jordens I."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Rudiger S.G."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Slootstra J.W."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Maurice M.M."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Tauriello D.V."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Kirchner K."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Schwamborn K."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Noutsou M."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Bouwman B.A."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/author | "Kruitwagen T."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/pages | "E812-20"xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/title | "Wnt/beta-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled."xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22411803 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22411803 |
| http://purl.uniprot.org/citations/22411803 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22411803 |
| http://purl.uniprot.org/uniprot/#_P56704-mappedCitation-22411803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22411803 |
| http://purl.uniprot.org/uniprot/#_Q149L3-mappedCitation-22411803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22411803 |
| http://purl.uniprot.org/uniprot/#_Q14332-mappedCitation-22411803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22411803 |
| http://purl.uniprot.org/uniprot/#_P51141-mappedCitation-22411803 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22411803 |