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http://purl.uniprot.org/citations/22412924http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22412924http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22412924http://www.w3.org/2000/01/rdf-schema#comment"

Background

Lying downstream of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other biological systems. To gain further insight into immune system evolution, we have performed a comprehensive bioinformatic analysis of the JAK-STAT pathway components, including the key negative regulators of this pathway, the SH2-domain containing tyrosine phosphatase (SHP), Protein inhibitors against Stats (PIAS), and Suppressor of cytokine signaling (SOCS) proteins across a diverse range of organisms.

Results

Our analysis has demonstrated significant expansion of JAK-STAT pathway components co-incident with the emergence of adaptive immunity, with whole genome duplication being the principal mechanism for generating this additional diversity. In contrast, expansion of upstream cytokine receptors appears to be a pivotal driver for the differential diversification of specific pathway components.

Conclusion

Diversification of JAK-STAT pathway components during early vertebrate development occurred concurrently with a major expansion of upstream cytokine receptors and two rounds of whole genome duplications. This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0032777"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0032777"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"Ward A.C."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"Ward A.C."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"Liongue C."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"Liongue C."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"O'Sullivan L.A."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"O'Sullivan L.A."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/author"Trengove M.C."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/name"PLoS ONE"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/name"PLoS ONE"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/pages"E32777"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/pages"E32777"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/title"Evolution of JAK-STAT pathway components: mechanisms and role in immune system development."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/title"Evolution of JAK-STAT pathway components: mechanisms and role in immune system development."xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/22412924http://purl.uniprot.org/core/volume"7"xsd:string
http://purl.uniprot.org/citations/22412924http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22412924
http://purl.uniprot.org/citations/22412924http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22412924
http://purl.uniprot.org/citations/22412924http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22412924
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