| http://purl.uniprot.org/citations/22417827 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22417827 | http://www.w3.org/2000/01/rdf-schema#comment | "Prohibitins (prohibitin-1 and -2) comprise a family of highly conserved proteins that are mainly localized to mitochondria. Recent studies showed that prohibitins are up-regulated upon T cell activation and play an essential role in maintaining mitochondrial homeostasis. In the present study, we found that a considerable proportion of prohibitin-1 and -2 induced in response to T cell activation was expressed on the surface of activated T cells. When mouse and human T cells were stimulated with PMA and ionomycin, prohibitins expressed on the cell surface were increased significantly, peaking at 48 h after stimulation. Stimulation of mouse T cells with anti-CD3 and anti-CD28 antibodies also remarkably induced the cell surface expression of prohibitins. Their expression on the cell surface was also detected in T cell leukemia cells such as Jurkat cells. In Jurkat cells, prohibitin-1 and -2 were co-localized with CD3 on the cell surface, and anti-CD3 antibody-induced signaling, the MAP kinase cascade, was inhibited on treatment with protein A magnetic beads co-conjugated with anti-CD3 antibody and anti-prohibitin-1 or anti-prohibitin-2 antibody. These results suggest that prohibitins expressed on the surface of activated T cells are involved in the T cell receptor-mediated signaling cascade."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.02.149"xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Inoue M."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Toda M."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Akita K."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Ishida A."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Nakada H."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Tanida S."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/author | "Yurugi H."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/pages | "275-280"xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/title | "Expression of prohibitins on the surface of activated T cells."xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://purl.uniprot.org/core/volume | "420"xsd:string |
| http://purl.uniprot.org/citations/22417827 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22417827 |
| http://purl.uniprot.org/citations/22417827 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22417827 |
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