| http://purl.uniprot.org/citations/22418270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22418270 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene polymorphisms of cytotoxic T lymphocyte associated antigen 4 (CTLA4) play an influential role in the graft rejection and long-term clinical outcome of organ transplantation. We investigated the associations of five CTLA4 single nucleotide polymorphisms (SNPs) (rs733618T/C, rs4553808A/G, rs5742909C/T, rs231775G/A, rs3087243G/A) on the early acute rejection (AR) of Chinese deceased donor renal transplantation recipients. Genotyping of the CTLA4 SNPs was performed in 167 deceased donor renal transplantation recipients. Each patient underwent a 6-month follow-up observation for AR. The incidence of AR during the 6 months post-transplantation was 26.9% (45 out of 167 patients). Patients experiencing AR were found to have a higher frequency of the rs733618TT genotype and T allele (p=0.000 and p=0.002, respectively). While the haplotype CACAG was merely observed in non-AR group (corrected p=0.000), the frequency of haplotype TACGG was significantly higher in AR group than in non-AR group even after 50,000 permutation tests (corrected p=0.018). In conclusion, these polymorphisms statistically significantly associated with acute renal allograft rejection may be considered as a risk factor of AR in Chinese renal transplantation recipients except for haplotype CACAG as a protective one."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.trim.2012.02.005"xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Fan Y."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Guo Y.F."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Gao J.W."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Bao E.D."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/author | "Qiu J.X."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/name | "Transpl Immunol"xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/pages | "207-211"xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/title | "Polymorphisms in cytotoxic T lymphocyte associated antigen-4 influence the rate of acute rejection after renal transplantation in 167 Chinese recipients."xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22418270 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22418270 |
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| http://purl.uniprot.org/uniprot/#_Q0Q5F1-mappedCitation-22418270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22418270 |
| http://purl.uniprot.org/uniprot/#_P16410-mappedCitation-22418270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22418270 |
| http://purl.uniprot.org/uniprot/#_Q6GR94-mappedCitation-22418270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22418270 |