| http://purl.uniprot.org/citations/22418839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22418839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22418839 | http://www.w3.org/2000/01/rdf-schema#comment | "Human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9) is a specific substrate-recognition subunit of an elongin C-cullin-SOCS box E3 ubiquitin ligase complex. It recognizes its substrate, brain type creatine kinase (CKB), using the ankyrin repeat domain; and facilitates the polyubiquitination of CKB to mediate proteasomal degradation through the SOCS box domain. HASB9-2 is an isoform of hASB9 that contains one ankyrin repeat domain. In this study, the crystal structure of hASB9-2 is shown at 2.2-Å resolution using molecular replacement. Overall, hASB9-2 forms a slightly curved arch with a characteristic L-shaped cross-section. Amino acid substitution analysis based on docking experiments revealed that His103 and Phe107 in hASB9-2 are essential for binding to CKB. Analysis of truncation mutants demonstrated that the first six ankyrin repeats along with the N-terminal region of hASB9-2 contribute to the interaction with CKB."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10930-012-9401-1"xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10930-012-9401-1"xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Gong W."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Gong W."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Yang Z."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Ji C."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Ji C."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Mao Y."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Fan S."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Fan S."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Fei X."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/author | "Fei X."xsd:string |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22418839 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |