| http://purl.uniprot.org/citations/22419821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22419821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22419821 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiogenesis-the growth of new blood vessels from preexisting vessels-is an important physiological process and is considered to play a key role in tumor growth and metastasis. We identified the immunoglobulin-containing and proline-rich receptor-1 (IGPR-1, also called TMIGD2) gene as a novel cell adhesion receptor that is expressed in various human organs and tissues, mainly in cells with epithelium and endothelium origins. IGPR-1 regulates cellular morphology, homophilic cell aggregation, and cell-cell interaction. IGPR-1 activity also modulates actin stress fiber formation and focal adhesion and reduces cell migration. Silencing of expression of IGPR-1 by small interfering RNA (siRNA) and by ectopic overexpression in endothelial cells showed that IGPR-1 regulates capillary tube formation in vitro, and B16F melanoma cells engineered to express IGPR-1 displayed extensive angiogenesis in the mouse Matrigel angiogenesis model. Moreover, IGPR-1, through its proline-rich cytoplasmic domain, associates with multiple Src homology 3 (SH3)-containing signaling proteins, including SH3 protein interacting with Nck (SPIN90/WISH), bullous pemphigoid antigen-1, and calcium channel β2. Silencing of expression of SPIN90/WISH by siRNA in endothelial cells showed that SPIN90/WISH is required for capillary tube formation. These features of IGPR-1 suggest that IGPR-1 is a novel receptor that plays an important role in cell-cell interaction, cell migration, and angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-11-0934"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-11-0934"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Hartsough E."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Hartsough E."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Mahoney J.E."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Mahoney J.E."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Meyer R.D."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Meyer R.D."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Rahimi N."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Rahimi N."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Rezazadeh K."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/author | "Rezazadeh K."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/pages | "1646-1656"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/pages | "1646-1656"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/title | "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/title | "Identification of IGPR-1 as a novel adhesion molecule involved in angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22419821 | http://purl.uniprot.org/core/volume | "23"xsd:string |