Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/22420900http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22420900http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22420900http://www.w3.org/2000/01/rdf-schema#comment"

Background

Human herpesvirus 8 (HHV-8) seroprevalence ranges between less than 5% in Europe and North America and 50% to 70% in sub-Saharan Africa. Evidence of HHV-8 transfusion transmission is only indirect. We conducted a serologic (anti-HHV-8) and molecular (HHV-8 DNA) study of samples from paired donor-immunocompetent recipients transfused with whole blood.

Study design and methods

Samples from 252 donor-recipient pairs were tested. Immunoglobulin G to HHV-8 was detected with enzyme immunoassays and confirmed with an in-house immunofluorescence assay. The cellular fraction from seroreactive donors and their recipients was tested for HHV-8 DNA.

Results

Anti-HHV-8 was positive (reactive in two or more assays) in 28 (11%) patients and 16 (6%) donors. Of 12 seronegative recipients (at risk of transmission) receiving seropositive blood, one very likely transmission was identified (8.3% confidence interval, 0%-23%). The donor blood contained HHV-8 DNA and his and four other donors' sequences clustered separately from recorded genotypes with a 97% bootstrap constituting a distinct genotype.

Conclusions

HHV-8 is transmitted in Ghana but does not carry clinical consequences since most patients are immunocompetent. The clinical risk will increase with the availability of immunosuppressive drugs in sub-Saharan Africa. We propose that a new genotype (HHV-8-G for Ghana) be added to the current nomenclature."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/name"Transfusion"xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/name"Transfusion"xsd:string
http://purl.uniprot.org/citations/22420900http://purl.org/dc/terms/identifier"doi:10.1111/j.1537-2995.2012.03607.x"xsd:string
http://purl.uniprot.org/citations/22420900http://purl.org/dc/terms/identifier"doi:10.1111/j.1537-2995.2012.03607.x"xsd:string
http://purl.uniprot.org/citations/22420900http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22420900
http://purl.uniprot.org/citations/22420900http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22420900
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Allain J.P."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Allain J.P."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Candotti D."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Candotti D."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Owusu-Ofori S."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Owusu-Ofori S."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Marcelin A.G."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Marcelin A.G."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Gobbini F."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/author"Gobbini F."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/pages"2294-2299"xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/pages"2294-2299"xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/title"Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa."xsd:string
http://purl.uniprot.org/citations/22420900http://purl.uniprot.org/core/title"Human herpesvirus 8 transfusion transmission in Ghana, an endemic region of West Africa."xsd:string
▶