| http://purl.uniprot.org/citations/22424773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22424773 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22424773 | http://www.w3.org/2000/01/rdf-schema#comment | "The regulatory networks of the DNA damage response (DDR) encompass many proteins and posttranslational modifications. Here, we use mass spectrometry-based proteomics to analyze the systems-wide response to DNA damage by parallel quantification of the DDR-regulated phosphoproteome, acetylome, and proteome. We show that phosphorylation-dependent signaling networks are regulated more strongly compared to acetylation. Among the phosphorylated proteins identified are many putative substrates of DNA-PK, ATM, and ATR kinases, but a majority of phosphorylated proteins do not share the ATM/ATR/DNA-PK target consensus motif, suggesting an important role of downstream kinases in amplifying DDR signals. We show that the splicing-regulator phosphatase PPM1G is recruited to sites of DNA damage, while the splicing-associated protein THRAP3 is excluded from these regions. Moreover, THRAP3 depletion causes cellular hypersensitivity to DNA-damaging agents. Collectively, these data broaden our knowledge of DNA damage signaling networks and highlight an important link between RNA metabolism and DNA repair."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.01.026"xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2012.01.026"xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Choudhary C."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Mann M."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Olsen J.V."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Olsen J.V."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Lukashchuk N."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Lukashchuk N."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Weinert B.T."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Weinert B.T."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Baskcomb L."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Baskcomb L."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Beli P."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Beli P."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Wagner S.A."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/author | "Wagner S.A."xsd:string |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22424773 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |