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http://purl.uniprot.org/citations/22425903http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22425903http://www.w3.org/2000/01/rdf-schema#comment"

Aims

Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model.

Methods and results

NecroX-5 reduced mitochondrial oxidative stress, prevented the collapse in mitochondrial membrane potential, improved mitochondrial oxygen consumption, and suppressed mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model. Furthermore, NecroX-5 reduced the ouabain- or histamine-induced increase in mitochondrial Ca(2+).

Conclusion

These findings suggest that NecroX-5 may act as a mitochondrial Ca(2+) uniporter inhibitor to protect cardiac mitochondria against HR damage."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.org/dc/terms/identifier"doi:10.1093/cvr/cvs122"xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Han J."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Kim S.H."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Kim H.K."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Kim N."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Lee S.R."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Ko K.S."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Rhee B.D."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Heo H.J."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Thu V.T."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Hanh T.M."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Ko T.H."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/author"Long l.e. T."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/name"Cardiovasc Res"xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/pages"342-350"xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/title"NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter."xsd:string
http://purl.uniprot.org/citations/22425903http://purl.uniprot.org/core/volume"94"xsd:string
http://purl.uniprot.org/citations/22425903http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22425903
http://purl.uniprot.org/citations/22425903http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22425903
http://purl.uniprot.org/uniprot/A0A8I6A2V9#attribution-2AA5A5B96B73AFEB97ACA37171D7F321http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/22425903
http://purl.uniprot.org/uniprot/M0RDI5#attribution-2AA5A5B96B73AFEB97ACA37171D7F321http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/22425903
http://purl.uniprot.org/uniprot/A6K3V1#attribution-2AA5A5B96B73AFEB97ACA37171D7F321http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/22425903
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