| http://purl.uniprot.org/citations/22426253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22426253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22426253 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendrites from a single neuron may be highly branched but typically do not overlap. Self-avoidance behavior has been shown to depend on cell-specific membrane proteins that trigger mutual repulsion. Here we report the unexpected discovery that a diffusible cue, the axon guidance protein UNC-6 (Netrin), is required for self-avoidance of sister dendrites from the PVD nociceptive neuron in Caenorhabditis elegans. We used time-lapse imaging to show that dendrites fail to withdraw upon mutual contact in the absence of UNC-6 signaling. We propose a model in which the UNC-40 (Deleted in Colorectal Cancer; DCC) receptor captures UNC-6 at the tips of growing dendrites for interaction with UNC-5 on the apposing branch to induce mutual repulsion. UNC-40 also responds to dendritic contact through another pathway that is independent of UNC-6. Our findings offer a new model for how an evolutionarily conserved morphogenic cue and its cognate receptors can pattern a fundamental feature of dendritic architecture."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3065"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3065"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Smith C.J."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Watson J.D."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Watson J.D."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Miller D.M. III"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Miller D.M. III"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Colon-Ramos D.A."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "Colon-Ramos D.A."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "VanHoven M.K."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/author | "VanHoven M.K."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/name | "Nat. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/pages | "731-737"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/pages | "731-737"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/title | "Netrin (UNC-6) mediates dendritic self-avoidance."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/title | "Netrin (UNC-6) mediates dendritic self-avoidance."xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/22426253 | http://purl.uniprot.org/core/volume | "15"xsd:string |