| http://purl.uniprot.org/citations/22431517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22431517 | http://www.w3.org/2000/01/rdf-schema#comment | "Ms1/STARS is a novel muscle-specific actin-binding protein that specifically modulates the myocardin-related transcription factor (MRTF)-serum response factor (SRF) regulatory axis within striated muscle. This ms1/STARS-dependent regulatory axis is of central importance within the cardiac gene regulatory network and has been implicated in cardiac development and postnatal cardiac function/homeostasis. The dysregulation of ms1/STARS is associated with and causative of pathological cardiac phenotypes, including cardiac hypertrophy and cardiomyopathy. In order to gain an understanding of the mechanisms governing ms1/STARS expression in the heart, we have coupled a comparative genomic in silico analysis with reporter, gain-of-function, and loss-of-function approaches. Through this integrated analysis, we have identified three evolutionarily conserved regions (ECRs), α, SINA, and DINA, that act as cis-regulatory modules and confer differential cardiac cell-specific activity. Two of these ECRs, α and DINA, displayed distinct regulatory sensitivity to the core cardiac transcription factor GATA4. Overall, our results demonstrate that within embryonic, neonatal, and adult hearts, GATA4 represses ms1/STARS expression with the pathologically associated depletion of GATA4 (type 1/type 2 diabetic models), resulting in ms1/STARS upregulation. This GATA4-dependent repression of ms1/STARS expression has major implications for MRTF-SRF signaling in the context of cardiac development and disease."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.06374-11"xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Liang Q."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Kobayashi S."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Menick D.R."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Chong N.W."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Samani N.J."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "He A."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Peterson R.E."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Pu W.T."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Ounzain S."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/author | "Motterle A."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/pages | "1830-1843"xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/title | "Cardiac expression of ms1/STARS, a novel gene involved in cardiac development and disease, is regulated by GATA4."xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22431517 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22431517 |
| http://purl.uniprot.org/citations/22431517 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22431517 |
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| http://purl.uniprot.org/uniprot/#_D3Z5M4-mappedCitation-22431517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22431517 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1N7-mappedCitation-22431517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22431517 |
| http://purl.uniprot.org/uniprot/#_A4K4Z6-mappedCitation-22431517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22431517 |
| http://purl.uniprot.org/uniprot/#_A0A494B983-mappedCitation-22431517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22431517 |