| http://purl.uniprot.org/citations/22431591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22431591 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22431591 | http://www.w3.org/2000/01/rdf-schema#comment | "How the human pathogen Streptococcus pneumoniae coordinates cell-wall synthesis during growth and division to achieve its characteristic oval shape is poorly understood. The conserved eukaryotic-type Ser/Thr kinase of S. pneumoniae, StkP, previously was reported to phosphorylate the cell-division protein DivIVA. Consistent with a role in cell division, GFP-StkP and its cognate phosphatase, GFP-PhpP, both localize to the division site. StkP localization depends on its penicillin-binding protein and Ser/Thr-associated domains that likely sense uncross-linked peptidoglycan, because StkP and PhpP delocalize in the presence of antibiotics that target the latest stages of cell-wall biosynthesis and in cells that have stopped dividing. Time-lapse microscopy shows that StkP displays an intermediate timing of recruitment to midcell: StkP arrives shortly after FtsA but before DivIVA. Furthermore, StkP remains at midcell longer than FtsA, until division is complete. Cells mutated for stkP are perturbed in cell-wall synthesis and display elongated morphologies with multiple, often unconstricted, FtsA and DivIVA rings. The data show that StkP plays an important role in regulating cell-wall synthesis and controls correct septum progression and closure. Overall, our results indicate that StkP signals information about the cell-wall status to key cell-division proteins and in this way acts as a regulator of cell division."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1119172109"xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1119172109"xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Branny P."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Branny P."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Novakova L."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Novakova L."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Veening J.W."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Veening J.W."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Massidda O."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Massidda O."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Fadda D."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Fadda D."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Beilharz K."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/author | "Beilharz K."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/pages | "E905-E913"xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/pages | "E905-E913"xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/title | "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."xsd:string |
| http://purl.uniprot.org/citations/22431591 | http://purl.uniprot.org/core/title | "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."xsd:string |