| http://purl.uniprot.org/citations/22432011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22432011 | http://www.w3.org/2000/01/rdf-schema#comment | "Organisms are remarkably adapted to diverse environments by specialized metabolisms, morphology, or behaviors. To address the molecular mechanisms underlying environmental adaptation, we have utilized a Drosophila melanogaster line, termed "Dark-fly", which has been maintained in constant dark conditions for 57 years (1400 generations). We found that Dark-fly exhibited higher fecundity in dark than in light conditions, indicating that Dark-fly possesses some traits advantageous in darkness. Using next-generation sequencing technology, we determined the whole genome sequence of Dark-fly and identified approximately 220,000 single nucleotide polymorphisms (SNPs) and 4,700 insertions or deletions (InDels) in the Dark-fly genome compared to the genome of the Oregon-R-S strain, a control strain. 1.8% of SNPs were classified as non-synonymous SNPs (nsSNPs: i.e., they alter the amino acid sequence of gene products). Among them, we detected 28 nonsense mutations (i.e., they produce a stop codon in the protein sequence) in the Dark-fly genome. These included genes encoding an olfactory receptor and a light receptor. We also searched runs of homozygosity (ROH) regions as putative regions selected during the population history, and found 21 ROH regions in the Dark-fly genome. We identified 241 genes carrying nsSNPs or InDels in the ROH regions. These include a cluster of alpha-esterase genes that are involved in detoxification processes. Furthermore, analysis of structural variants in the Dark-fly genome showed the deletion of a gene related to fatty acid metabolism. Our results revealed unique features of the Dark-fly genome and provided a list of potential candidate genes involved in environmental adaptation."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0033288"xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Toyoda A."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Fujiyama A."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Fuse N."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Sugiyama Y."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Nishimura O."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Agata K."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Aizu T."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/author | "Izutsu M."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/pages | "e33288"xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/title | "Genome features of "Dark-fly", a Drosophila line reared long-term in a dark environment."xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22432011 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22432011 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KEK0-mappedCitation-22432011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22432011 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KEX9-mappedCitation-22432011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22432011 |