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http://purl.uniprot.org/citations/22432908http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22432908http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To check whether individual or combined mutated genotypes for Ala-9Val (Mn-SOD) and Arg213Gly (EC-SOD) are associated with preeclampsia; to check the influence of the mutated genotypes on the degree of severity and perinatal outcome of preeclampsia.

Methods

We genotyped 97 pregnant women (47 with preeclampsia and 50 normal pregnant women) using PCR-RFLP analysis.

Results

The Val/Val (Mn-SOD) genotype (OR 5.99, p = 0.004) but not the Gly/Gly (EC-SOD) genotype (OR 4.23, p = 0.027) was significantly associated with preeclampsia. Higher frequency of both polymorphisms in women with preeclampsia (42.55%) compared to normal pregnant women (8%). Higher frequency of women diagnosed with PIH (27.27%, OR 4.31), mild (50%, OR 11.5) and severe preeclampsia (37.5%, OR 6.9) positive for both polymorphism compared to control women (8%). There was a statistically significant difference in gestational age at delivery according to Mn-SOD (Ala/Ala vs. Val/Val, 39 ± 1.41 weeks vs. 32.77 ± 3.7 weeks) and EC-SOD genotypes (Arg/Arg vs. Gly/Gly, 37.05 ± 3.18 weeks vs. 31.5 ± 3.84 weeks). There also was a statistically significant difference in birth weight according to Mn-SOD (grams, Ala/Ala vs. Val/Val, 3080 ± 481.66 vs. 2376.92 ± 916.88) and EC-SOD genotypes (grams, Arg/Arg vs. Gly/Gly, 2934.09 ± 662.14 vs. 2080 ± 721.19).

Conclusions

Our study demonstrates a relationship between these two mutated genes, the clinical severity and the perinatal outcome of preeclampsia."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.org/dc/terms/identifier"doi:10.3109/14767058.2011.599078"xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Drugan C."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Stamatian F."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Procopciuc L.M."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Olteanu I."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Caracostea G."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/author"Nemeti G."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/name"J Matern Fetal Neonatal Med"xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/pages"895-900"xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/title"The Ala-9Val (Mn-SOD) and Arg213Gly (EC-SOD) polymorphisms in the pathogenesis of preeclampsia in Romanian women: association with the severity and outcome of preeclampsia."xsd:string
http://purl.uniprot.org/citations/22432908http://purl.uniprot.org/core/volume"25"xsd:string
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