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http://purl.uniprot.org/citations/22433836http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22433836http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Related transcriptional enhancer factor 1 (RTEF-1) is a key transcriptional regulator in endothelial function. In this study, we investigated a possible role for RTEF-1 in the regulation of microvascular relaxation and the underlying mechanism involved. Activation of fibroblast growth factor receptor 1 (FGFR1) by FGFs increases vasodilation, although transcriptional control of the molecular mechanisms underlying FGFR1 is still unclear.

Materials and methods

We demonstrated that RTEF-1 stimulated FGFR1 expression at the transcriptional level, specifically an area including Sp1 elements, as evidenced by promoter assays. Additionally, RTEF-1 increased FGFR1 mRNA and protein expression in vitro and in VE-cadherin-promoted RTEF-1 (VE-Cad/RTEF-1) transgenic mice, whereas RTEF-1 siRNA blocked the upregulation of FGFR1 expression. Furthermore, increased endothelial-dependent microvessel relaxation was observed in the coronary arteries of VE-Cad/RTEF-1 mice, and increased proliferation was observed in RTEF-1-overexpressing cells, both of which correlated to increased FGF/FGFR1 signaling and endothelial nitric oxide synthase (eNOS) upregulation. Our results indicate that RTEF-1 acts as a transcriptional stimulator of FGFR1 and is involved in FGF pathways by increasing microvessel dilatation via eNOS.

Conclusions

These findings suggest that RTEF-1 plays an important role in FGFR1-stimulated vasodilatation. Understanding the effect of RTEF-1 in microvessel relaxation may provide beneficial knowledge in improving treatments in regards to ischemic vascular disorders."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.org/dc/terms/identifier"doi:10.1159/000335180"xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Liu Y."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Li J."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Song Q."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"He P."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Shie J.L."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Messmer-Blust A.F."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Lubenec I."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/author"Sellke F."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/name"J Vasc Res"xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/pages"249-259"xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/title"Related transcriptional enhancer factor 1 increases endothelial-dependent microvascular relaxation and proliferation."xsd:string
http://purl.uniprot.org/citations/22433836http://purl.uniprot.org/core/volume"49"xsd:string
http://purl.uniprot.org/citations/22433836http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22433836
http://purl.uniprot.org/citations/22433836http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22433836
http://purl.uniprot.org/uniprot/#_Q15561-mappedCitation-22433836http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22433836
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http://purl.uniprot.org/uniprot/#_D3DUQ6-mappedCitation-22433836http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22433836
http://purl.uniprot.org/uniprot/#_Q53GI4-mappedCitation-22433836http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22433836
http://purl.uniprot.org/uniprot/Q15561http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22433836
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