| http://purl.uniprot.org/citations/22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22434822 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding the mechanisms that control processing of the amyloid precursor protein (APP) to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. Here, we show that siRNA-mediated loss of calsyntenin-1 in cultured neurons alters APP processing to increase production of Aβ. We also show that calsyntenin-1 is reduced in Alzheimer's disease brains and that the extent of this reduction correlates with increased Aβ levels. Calsyntenin-1 is a ligand for kinesin-1 light chains and APP is transported through axons on kinesin-1 molecular motors. Defects in axonal transport are an early pathological feature in Alzheimer's disease and defective APP transport is known to increase Aβ production. We show that calsyntenin-1 and APP are co-transported through axons and that siRNA-induced loss of calsyntenin-1 markedly disrupts axonal transport of APP. Thus, perturbation to axonal transport of APP on calsyntenin-1 containing carriers induces alterations to APP processing that increase production of Aβ. Together, our findings suggest that disruption of calsyntenin-1-associated axonal transport of APP is a pathogenic mechanism in Alzheimer's disease."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/dds109"xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Miller C.C."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Perkinton M.S."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Vagnoni A."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Noble W."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Francis P.T."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/author | "Gray E.H."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/pages | "2845-2854"xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/title | "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Abeta production."xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/22434822 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22434822 |
| http://purl.uniprot.org/citations/22434822 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22434822 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MRG2-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_A0A140VJC8-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_A0A218KGR2-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_A0A8F9R5D5-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_B4DGD0-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_B3KMD3-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_B4DMD5-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_B4DQM1-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |
| http://purl.uniprot.org/uniprot/#_B4DM00-mappedCitation-22434822 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22434822 |