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| http://purl.uniprot.org/citations/22435550 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear factor-κB (NF-κB) pathway is a critical regulator of innate and adaptive immunity. Noncanonical K63-linked polyubiquitination plays a key regulatory role in NF-κB signaling pathways by functioning as a scaffold to recruit kinase complexes containing ubiquitin-binding domains. Ubiquitination is balanced by deubiquitinases that cleave polyubiquitin chains and oppose the function of E3 ubiquitin ligases. Deubiquitinases therefore play an important role in the termination of NF-κB signaling and the resolution of inflammation. In this review, we focus on NF-κB regulation by deubiquitinases with an emphasis on A20 and CYLD. Deubiquitinases and the ubiquitin/proteasome components that regulate NF-κB may serve as novel therapeutic targets for inflammatory diseases and cancer."xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-065x.2012.01100.x"xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/author | "Dixit V.M."xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/author | "Harhaj E.W."xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/name | "Immunol Rev"xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/pages | "107-124"xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/title | "Regulation of NF-kappaB by deubiquitinases."xsd:string |
| http://purl.uniprot.org/citations/22435550 | http://purl.uniprot.org/core/volume | "246"xsd:string |
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